Table 3.

Univariate and multivariate analyses of clinicopathologic variables affecting RFS in patients with A: stage II CRC and B: stage III CRC

Variables		No. Patients	Univariate analysis		Multivariate analysis
			Hazard ratio (95 % CI)	p value	Hazard ratio (95 % CI)	p value
≪stage II≫
Age	< 70 years	53	2.984 (1.249–7.130)	0.014	2.798 (1.168–6.702)	0.021
	≥ 70 years	34
Gender	male	53	0.506 (0.198–1.294)	0.155
	female	34
Histology (TNM 7th)	G1	36	1.041 (0.445–2.438)	0.926
	G2, G3	51
Tumor location	colon	57	1.723 (0.744–3.989)	0.204
	rectum	30
Depth of tumor invasion (TNM 7th)	T1-3	62	1.269 (0.517–3.115)	0.603
	T4	25
Lymphatic invasion	(-)	36	1.292 (0.541–3.083)	0.564
	(+)	51
Venous invasion	(-)	11	1.550 (0.362–6.635)	0.555
	(+)	76
Examined lymph nodes	< 12	21	0.820 (0.321–2.097)	0.679
	≥ 12	66
CEA	< 5 ng/ml	62	1.153 (0.450–2.954)	0.767
	≥ 5 ng/ml	25
TNIK expression	low	55	2.511 (1.073–5.877)	0.034	2.323 (0.990–5.452)	0.053
	high	32
Variables		No. Patients	Univariate analysis		Multivariate analysis
			Hazard ratio (95 % CI)	p value	Hazard ratio (95 % CI)	p value
≪stage III≫
Age	< 70 years	60	1.032 (0.536–1.988)	0.925
	≥ 70 years	25
Gender	male	60	0.681 (0.334–1.385)	0.289
	female	25
Histology (TNM 7th)	G1	24	1.838 (0.878–3.846)	0.106
	G2, G3	61
Tumor location	colon	48	1.540 (0.839–2.824)	0.163
	rectum	37
Depth of tumor invasion (TNM 7th)	T1-3	43	1.308	0.388
	T4	42
Lymphatic invasion	(-)	4		0.706
	(+)	81
Venous invasion	(-)	3		0.570
	(+)	82
Lymph node metastasis (TNM 7th)	N1	48		0.194
	N2	37
CEA	< 5 ng/ml	47	1.918 (1.042–3.530)	0.036	1.678 (0.903–3.120)	0.102
	≥ 5 ng/ml	38
TNIK expression	low	48	2.345 (1.256–4.378)	0.007	2.141 (1.136–4.038)	0.019
	high	37