Table 4.
BL infection intensity Category | District | Sentinel Site | No. in cohort (n) | BL FOI (wppy) | Infection intensity with S. mansoni (epg) | Ratio of FOI in relation to BL | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
BL | FY1 | FY2 | FY3 | ζ1 | ζ2 | ζ3 | |||||
High | Bugiri | Buyondo | 75 | 26.97 | 444.4 | 59.4a | 16.7a | 3.5a | 0.179a | 0.035a | 0.015a |
Wakawaka | 30 | 30.01 | 746.3 | 384.8 | 539.1 | 160.0 | 1.574b | 1.698b | 0.945 | ||
Busia | Buloosi | 72 | 24.78 | 598.1 | 99.7a | 52.4a | 24.0a | 0.357a | 0.220a | 0.099a | |
Hoima | Kibiro | 57 | 54.87 | 1000.3 | 408.6a | 153.7a | 247.5a | 1.038 | 0.454a | 0.553a | |
Runga | 20 | 47.35 | 710.4 | 404.6 | 230.4a | 110.4a | 1.444 | 0.976 | 0.727 | ||
Tonya | 9 | 61.81 | 1096.0 | 228.0a | 48.0a | 48.0a | 0.566 | 0.088a | 0.001a | ||
Masindi | Walukubwa | 20 | 62.28 | 895.2 | 314.2a | 108.9a | 974.8 | 0.591 | 0.266a | 1.346 | |
Mayuge | Bugoto LV | 45 | 24.51 | 616.5 | 123.1a | 61.8a | 50.4a | 0.484a | 0.235a | 0.085a | |
Bwondha | 33 | 28.94 | 529.5 | 83.3a | 133.8a | 61.1a | 0.558a | 0.604a | 0.263a | ||
Nebbi | Panyimur | 67 | 31.72 | 597.6 | 327.9a | 84.6a | 49.1a | 1.993b | 0.121a | 0.189a | |
Medium | Bugiri | Busiro | 57 | 12.06 | 154.9 | 141.4 | 51.1a | 108.5 | 1.891b | 0.572a | 1.312 |
Busia | Bwaniha | 70 | 20.38 | 386.1 | 58.7a | 25.0a | 42.7a | 0.513a | 0.187a | 0.251a | |
Hoima | Kasenyi | 55 | 15.46 | 299.1 | 347.5 | 208.9 | 201.3 | 1.626b | 0.969 | 1.264 | |
Masindi | Butiaba | 31 | 14.32 | 300.4 | 98.3 | 1.5a | 27.0a | 0.880 | 0.009a | 0.424a | |
Kabolwa | 23 | 14.59 | 452.9 | 43.8a | 0.0a | 0.0a | 0.198a | 0.001a | 0.001a | ||
Wanseko | 57 | 10.12 | 114.2 | 31.2 | 20.6a | 0.0a | 0.465a | 0.286a | 0.000a | ||
Nebbi | Kinju | 52 | 15.21 | 104.4 | 52.9 | 16.9a | 81.1 | 1.196 | 0.444a | 1.267 | |
Pokwero | 59 | 4.86 | 105.8 | 29.0a | 1.7a | 0.0a | 0.929 | 0.119a | 0.023a | ||
Low | Bugiri | Kibimba | 41 | 0.36 | 13.5 | 16.2 | 15.4 | 0.0a | 3.584b | 2.214b | 0.000a |
Kibuye | 46 | 3.58 | 41.7 | 8.7 | 16.2 | 15.7 | 0.844 | 1.325 | 1.817b | ||
Busia | Maduwa | 77 | 5.46 | 68.1 | 7.0a | 3.9a | 0.4a | 0.772a | 0.116a | 0.010a | |
Majanji | 64 | 1.66 | 27.8 | 2.2 | 1.5 | 0.0 | 0.064a | 0.059a | 0.000a | ||
Hoima | Kibanjwa | 103 | 0.02 | 0.2 | 0.0 | 0.0 | 0.0 | 0.000 | 0.000 | 0.000 | |
Mayuge | Bukizbu | 59 | 0.40 | 7.7 | 0.6a | 0.4a | 0.0a | 0.114a | 0.135a | 0.000a | |
Ikulwe | 46 | 0.04 | 0.5 | 0.0 | 0.0 | - | 0.246 | 0.000 | - | ||
Lwanika | 61 | 5.96 | 74.5 | 7.4a | 3.5a | 44.3 | 0.292a | 0.222a | 1.648b | ||
Moyo | Aliba | 39 | 1.38 | 62.2 | 2.1a | 5.7a | 2.7a | 0.056a | 0.244a | 0.103a | |
Dufile | 69 | 1.70 | 60.5 | 0.7a | 4.1a | 0.0a | 0.008a | 0.151a | 0.000a | ||
Etele | 71 | 0.16 | 7.4 | 8.7 | 16.4 | 0.0a | 2.882b | 9.789b | 0.000a | ||
Laropi | 68 | 1.40 | 41.6 | 0.0 | 1.1 | 0.0 | 0.000a | 0.052a | 0.000a | ||
Obongi | 50 | 0.35 | 34.1 | 1.5 | 0.5 | 0.0 | 0.324a | 0.10002a | 0.000a | ||
Nebbi | Pagwaya | 54 | 1.66 | 49.8 | 12.0 | 2.7a | 2.1a | 0.430a | 0.088a | 0.087a |
BL baseline, FOI force of infection expressed as the mean number of adult female parasites acquired per person per year; wppy: worms per person per year; epg: eggs per gram of faeces, FY1 follow-up year 1, FY2 follow-up year 2, FY3 follow-up year 3; ζ1, ζ2, ζ3: the relative change in the FOI at FY1, FY2, FY3, respectively, as a proportion of that at baseline; astatistically significant reduction in infection intensity or FOI from baseline; bstatistically significant increase in infection intensity or FOI from baseline
Note that the decision to allocate each sentinel site into high, medium, and low infection intensity categories was based on the infection intensity of the overall school/community at BL, rather than that of the longitudinal cohort selected to be followed up from that school/community (e.g. Kabolwa is classified in the medium category as the school-level intensity at BL was 339.4 epg; the cohort level was 452.9 epg). Any cohort with fewer than 20 individuals was excluded