Table 1.

Summary of Prdm gene expression and function in the nervous system

Prdm gene	Nervous system expression	Nervous system function	Intrinsic HMT activity	Direct DNA binding	References
Prdm1	CNS: photoreceptors	CNS: photoreceptor identity	No	Yes	[8, 108, 109, 120, 144–147]
	PNS: prechordal plate, branchial arches, Rohon-Beard neurons	PNS: branchial arch formation, Rohon-Beard specification
Prdm3	CNS: telencephalon, tegmentum, diencephalon, hindbrain	CNS: olfactory receptor development		Yes	[28, 34, 120, 148]
	PNS: branchial arches	PNS: craniofacial development
Prdm4	CNS: cerebral cortex	CNS: in vitro neural stem cell proliferation and differentiation	Yes		[149–151]
Prdm5	CNS: ventral spinal cord	PNS: development of the neuocranium		Yes	[9, 152, 153]
	PNS: neurocranium
Prdm6	CNS: spinal cord neurons		Yes	Yes	[74, 154]
Prdm8	CNS: telencephalon, retina, tegmentum, cerebellum, hindbrain and spinal cord	CNS: axonal outgrowth, neocortical neuron morphology	No	Yes	[15, 47, 72, 74, 120, 155]
Prdm10	PNS: neural crest	CNS: primary dendrite initiation			[156, 157]
Prdm12	CNS: telencephalon, tegmentum, cerebellum, midbrain, hindbrain and spinal cord p1 domain	CNS: formation of V1 interneurons, pain perception and sensory neuron development			[73, 74, 81, 120, 158, 159]
	PNS: cranial placodes
Prdm13	CNS: tegmentum, hindbrain, spinal cord, retina	CNS: GABAergic interneuron development		Yes	[43, 74, 80, 120]
Prdm14	CNS: ventral spinal cord	CNS: CaP motor neuron axonal projection		Yes	[46, 74, 120]
Prdm16	CNS: forebrain, telencephalon, hindbrain, retina	CNS: olfactory neuron development	Yes	Yes	[28, 34, 74, 120, 160]
	PNS: craniofacial structures	PNS: craniofacial development

Blank cells indicate categories were information is lacking in the literature. The list of expression domains and functions is not exhaustive