Table 1.
Observed responses in D-optimal mixture design for DTPA penta-ethyl ester matrixes.
| Independent Variables | Dependent Variables | |||||
|---|---|---|---|---|---|---|
| X1 | X2 | X3 | Y1 | Y2 | Y3 | |
| Batch | PVP (%) |
Eudragit® RL PO (%) |
α-Tocopherol (%) |
DTPA penta-ethyl ester loading (%) |
Water absorption (%) |
DTPA penta-ethyl ester remaininga (%) |
| 1 | 25 | 0 | 0 | 66.0 | 8.3 | 45.3 |
| 2 | 13.5625 | 11.0625 | 0.375 | 64.2 | 5.6 | 62.0 |
| 3 | 13.5625 | 10.3125 | 1.125 | 65.2 | 5.6 | 69.0 |
| 4 | 10 | 13.5 | 1.5 | 64.7 | 4.3 | 82.0 |
| 5 | 23.5 | 0 | 1.5 | 65.5 | 7.5 | 71.5 |
| 6 | 10 | 15 | 0 | 64.1 | 5.1 | 57.4 |
| 7 | 24.25 | 0 | 0.75 | 66.0 | 7.3 | 66.4 |
| 8 | 20.6875 | 3.5625 | 0.75 | 65.5 | 7.7 | 69.0 |
| 9 | 17.5 | 7.5 | 0 | 64.5 | 6.2 | 57.2 |
| 10 | 25 | 0 | 0 | 66.2 | 7.4 | 42.2 |
| 11 | 17.5 | 7.5 | 0 | 65.0 | 6.8 | 53.9 |
| 12 | 10 | 15 | 0 | 64.6 | 5.0 | 61.4 |
| 13 | 23.5 | 0 | 1.5 | 65.4 | 7.8 | 72.3 |
| 14 | 10 | 13.5 | 1.5 | 64.4 | 4.5 | 76.0 |
a
Stability after storage at 40 ± 2°C and 75 ± 5% relative humidity for one month.