Table 2.
Clinicopathological Association in the Various Sub-Groups
| Factors | Expression | Sub-group 1 n (%) | Sub-group 2 n (%) | Sub-group 3 n (%) | Sub-group 4 n (%) | p-Value |
|---|---|---|---|---|---|---|
| Lymph nodes | 0.645 | |||||
| 0 | 201 (63) | 194 (61) | 72 (53) | 33 (63) | ||
| 1–3 | 98 (30) | 104 (32) | 51 (37) | 15 (29) | ||
| >3 | 23 (7) | 22 (7) | 12 (10) | 4 (8) | ||
| Tumor size | 0.018 | |||||
| ≤1 cm | 44 (14) | 38 (12) | 12 (10) | 4 (8) | ||
| >1–2 cm | 18 (56) | 155 (49) | 62 (46) | 25 (48) | ||
| >2–5 cm | 95 (29) | 118 (37) | 59 (43) | 21 (40) | ||
| >5 cm | 2 (1) | 8 (2) | 3 (2) | 3 (6) | ||
| Grade | 0.000002 | |||||
| G1 (low) | 87 (27) | 58 (18) | 23 (17) | 9 (17) | ||
| G2 (intermediate) | 152 (47) | 136 (43) | 45 (33) | 15 (29) | ||
| G3 (High) | 82 (26) | 125 (39) | 68 (50) | 28 (54) | ||
| Mitosis | 0.00008 | |||||
| M1 (low, <10) | 178 (56) | 129 (39) | 46 (34) | 19 (36) | ||
| M2 (medium, 10–18) | 74 (23) | 114 (36) | 56 (42) | 21 (40) | ||
| M3 (high, >18) | 74 (23) | 114 (36) | 56 (42) | 21 (40) | ||
| Pleomorphism | 0.0005 | |||||
| Low | 10 (3) | 8 (2) | 5 (4) | 1 (2) | ||
| Moderate | 185 (58) | 161 (51) | 49 (36) | 20 (38) | ||
| High | 126 (39) | 148 (47) | 81 (60) | 31 (60) | ||
| Differentiation | 0.017 | |||||
| Well differentiated | 24 (8) | 24 (8) | 7 (5) | 1 (2) | ||
| Moderate differentiated | 144 (45) | 106 (33) | 48 (36) | 16 (31) | ||
| Poor differentiated | 153 (48) | 188 (59) | 80 (59) | 35 (67) | ||
| LVI | Presence | 98 (30) | 95 (30) | 63 (46) | 20 (39) | 0.003 |
| Tumor type | 0.006 | |||||
| Invasive ductal (NST) | 130 (44) | 149 (52) | 72 (57) | 26 (57) | ||
| Medullary | 0 (0) | 3 (1) | 1 (1) | 1 (2) | ||
| Tubular | 91 (31) | 61 (21) | 37 (29) | 5 (21) | ||
| Invasive lobular | 44 (15) | 39 (14) | 11 (9) | 6 (13) | ||
| Others | 29 (10) | 35 (12) | 6 (5) | 8 (17) | ||
| Ki67 | High expression | 147 (53) | 164 (60) | 75 (65) | 418 (59) | 0.012 |
| Bcl2 | Negative expression | 54 (18) | 47 (16) | 38 (30) | 156 (20) | 0.0004 |
| HER2 | Overexpression | 13 (4) | 17 (5) | 14 (10) | 1 (2) | 0.033 |
| Molecular sub-types | 0.014 | |||||
| Luminal A | 153 (51) | 132 (45) | 53 (41) | 14 (32) | ||
| Luminal B high Ki67 | 132 (44) | 146 (49) | 63 (48) | 29 (66) | ||
| Luminal B-HER2 over expression | 13 (5) | 17 (6) | 14 (11) | 1 (2) |
Bold values indicate significant p-values.
NST, non-specific type.