Fig. 4.
Duty cycle modulation with intrinsic parameters is fragile without slow regenerativity. Modulation of the duty cycle and duty cycle ratio by varying intrinsic parameters of neuron 1 (ḡPIR,1; in mS/cm2) and neuron 2 (ḡPIR,2; in mS/cm2) is robust with slow regenerativity but fragile without. Left: PIR only. Right: PIR + slow regenerativity. The proportion of simulations with stable rhythmic activity is shown for 10 simulations with 40% variability in ḡsyn and 20% variability in ḡPIR (see materials and methods for a description of detection of rhythm and proportion of half-center oscillations). For the case with slow regenerativity, enlarged views of the stable region for mean duty cycle (DC; top far right) and mean duty cycle ratio (DC ratio; bottom far right) from the 10 simulations are shown (see materials and methods for a description of duty cycle and duty cycle ratio). The arrows indicate the direction of DC and DC ratio modulation.