Many OFF and NR Tg P23H-1 RGCs have a rhythmic component in their spontaneous activity. A, left: example PSTHs and raster plots for representative P35 and P300 Tg P23H-1 OFF and P300 NR RGCs that exhibit rhythmic spontaneous activity. The dashed line represents the zero point for each PSTH. Right, representative 5-s rasters of the spontaneous activity (top) and frequency distributions (bottom) resulting from a fast Fourier transform (FFT) analysis for each RGC shown at left. B: distributions of the peak frequency of the FFT for Tg P23H-1 OFF RGCs at P35 (P35 OFF, i; n = 7), Tg P23H-1 OFF RGCs at P300 (P300 OFF, ii; n = 39), and Tg P23H-1 NR RGCs at P300 (P300 NR, iii; n = 30). The majority of FFT peak frequencies among P35 Tg P23H-1 OFF RGCs were between 13 and 18 Hz. The majority of FFT peak frequencies among Tg P23H-1 P300 OFF and NR RGCs were between 4 and 8 Hz.