Table 2.
Potential epigenomic markers of sepsis and SID.
| MicroRNA | Action | Effect |
|---|---|---|
| mir-6775 | -Silences CHRNA-7 gene -Augments RNF-128 |
Detrimental for sepsis/SID Promotes low grade inflammation and SAIS |
| miR-130 a | -Silences transcription of AQP-4 gene -Decreases cell motility and proliferation (lowers CD-69 and Th-17 lymphocytes) |
Beneficial sepsis/SID Lowers astroedema and Th-17 transmigration |
| miR-130b | -Increases cell motility and proliferation | |
| miR-155 | -Increases CD-69 response -Activated TLRs by binding to galectin-9 receptor -Turns innate immunity “on” |
Detrimental for sepsis/SID |
| miR-132 | -Acetylcholinesterase inhibition -Restores cholinergic transmission |
Beneficial for sepsis/SID |