NECR-dosage curves vs. different patient- or system- specific factors (phantom size, energy window, coincidence time window). (A) NECR-dosage curve as a function of NCAT phantom size class, (B) injected activity, such that max. NECR is triggered in (A), as a function of the size of the NCAT phantom, (C) NECR-dosage curve as a function of PET system energy window, (D) NECR-dosage curve as a function of PET system coincidence time window (CW). Obtained with permission from Karakatsanis et al. Monte-Carlo based characterization of the counting rate (NECR) response for personalized optimization of the administered activity in clinical PET imaging. Frontiers in Biomedical Technologies 2014; (1) 1 14-34. Copyright © Journal of Frontiers in Biomedical Technologies [13].