Table 1.
Comparison of differentially expressed genes in GM-BMM versus M-BMM of Paracoccidioides brasiliensis infected A/J and B10.A mice.
| Gene | Name | Fold changes (FC)∗ | |||
|---|---|---|---|---|---|
| A/J | B10.A | ||||
| M-BMM + Pb18 versus M-BMM | GM-BMM + Pb18 versus GM-BMM | M-BMM + Pb18 versus M-BMM | GM-BMM + Pb18 versus GM-BMM | ||
| Pattern of recognition receptor (PRR) | |||||
| TLR2 | Toll-like receptor 2 | −1.7 | 1.4 | 3.7 | −4.3 |
| TLR4 | Toll-like receptor 4 | 1.2 | 1.0 | 1.4 | −6.3 |
| TLR9 | Toll-like receptor 9 | −1.7 | 1.3 | 1.1 | −9.1 |
| Clec4n (Dectin-2) | C-type lectin domain family 4, member n | 6.4 | 2.1 | 6.1 | 1.6 |
| Clec7a (Dectin-1) | C-type lectin domain family 7, member a | 5.3 | 2.1 | 4.4 | 1.1 |
| Mrc1 (MR) | Mannose receptor, C-type 1 | 3.0 | 2.0 | −1.7 | −2.7 |
| Nlrp3 | NLR family, pyrin domain containing 3 | 1.3 | 2.9 | 4.8 | −1.9 |
| Scarf1 | Scavenger receptor class F, member 1 | 3.8 | −1.2 | −1.7 | −2.1 |
| Itgb2 | Integrin beta 2 | −1.4 | 1.2 | 2.7 | −3.0 |
| Mbl2 | Mannose-binding protein (protein C) 2 | 1.8 | 1.2 | −20.2 | 5.5 |
| CD14 | CD14 antigen | 2.0 | 3.0 | −1.3 | 8.8 |
| Itgam | Integrin alpha M | −1.4 | 1.6 | 1.3 | −3.6 |
| Colec12 | Collectin subfamily member 12 | 4.6 | 1.8 | 3.0 | −1.1 |
| PRR signal Transduction | |||||
| Casp-8 | Caspase-8 | 1.5 | 3.9 | 1.3 | 1.6 |
| Irak4 | Interleukin-1 receptor-associated kinase 4 | 1.3 | 2.1 | 1.5 | −2.6 |
| Mapk14 | Mitogen-activated protein kinase 14 | 1.1 | 1.3 | 2.3 | −3.6 |
| Mapk8 | Mitogen-activated protein kinase 8 | −1.7 | 1.4 | 2.0 | −1.6 |
| MyD88 | Myeloid differentiation primary response gene 88 | 1.5 | 4.6 | 2.6 | −3.0 |
| Bcl10 | B-cell leukemia/lymphoma 10 | 3.3 | 4.9 | 1.6 | 2.0 |
| Malt1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1 | 2.4 | 1.7 | 3.1 | −1.7 |
| Pycard | PYD and CARD domain containing | −3.1 | 1.3 | 1.7 | −5.5 |
| Plcg2 | Phospholipase C gamma 2 | −2.2 | −1.1 | 2.0 | −4.9 |
| Tirap (Mal) | Toll-interleukin-1 receptor (TIR) domain-containing adaptor protein | −1.1 | 1.3 | 1.4 | −7.1 |
| Raf1 | V-raf-leukemia viral oncogene 1 | 1.1 | 1.1 | 3.2 | −5.4 |
| Syk | Spleen tyrosine kinase | 1.5 | 1.3 | 2.9 | −6.1 |
| CD40 | CD40 antigen | −1.4 | 10.2 | 2.0 | 10.9 |
| Transcription factor and other proteins | |||||
| Map2k4 (MKK4) | Mitogen-activated protein kinase 4 | −1.3 | 1.8 | 1.9 | −4.5 |
| Mapk8 | Mitogen-activated protein kinase 8 | −1.7 | 1.4 | 2.0 | −1.6 |
| Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | −1.7 | 1.7 | 2.0 | 1.1 |
| Cytokines | |||||
| Csf2 (GM-CSF) | Colony stimulating factor 2 (granulocyte-macrophage) | −3.3 | 3.1 | −2.0 | −8.2 |
| Il1a | Interleukin-1 alpha | 5.4 | 15.0 | 4.5 | 5.8 |
| Il1b | Interleukin-1 beta | 1.8 | 31.4 | 3.4 | 7.0 |
| Il2 | Interleukin-2 | 1.3 | 124.7 | −6.5 | 5.0 |
| Il6 | Interleukin-6 | 1.0 | 61.7 | −1.4 | 4.4 |
| Il10 | Interleukin-10 | −1.8 | 101.1 | 1.5 | 26.9 |
| Il12a | Interleukin-12A | 1.3 | 4.4 | 1.8 | 3.5 |
| Il12b | Interleukin-12B | 1.5 | 21.7 | 1.5 | 9.0 |
| Il18 | Interleukin-18 | −1.2 | 2.4 | 1.0 | −1.3 |
| Il23a | Interleukin-23, alpha subunit p19 | 1.2 | 40.4 | 2.0 | 1.9 |
| Tnf | Tumor necrosis factor alpha | −1.0 | 18.7 | −1.1 | 18.6 |
| Chemokines | |||||
| Ccl5 | Chemokine (C-C motif) ligand 5 | 1.1 | 6.2 | 3.5 | 21.1 |
| Ccl12 | Chemokine (C-C motif) ligand 12 | −4.5 | 6.9 | 1.1 | 7.7 |
| Ccl20 | Chemokine (C-C motif) ligand 20 | −1.1 | 6.0 | 2.0 | 1.0 |
| Cxcl1 (KC) | Chemokine (C-X-C motif) ligand 1 | 8.8 | 53.9 | 6.5 | 19.4 |
| Cxcl3 | Chemokine (C-X-C motif) ligand 3 | 3.5 | 3.4 | 15.2 | 64.4 |
| Cxcl9 | Chemokine (C-X-C motif) ligand 9 | 2.1 | 3.9 | 1.5 | 3.7 |
| Cxcl10 (IP-10) | Chemokine (C-X-C motif) ligand 10 | −1.9 | 6.8 | 2.5 | 8.9 |
| Cxcl11 | Chemokine (C-X-C motif) ligand 11 | 2.1 | −1.2 | −2.7 | −1.3 |
| Other proteins | |||||
| Ptgs2 (Cox-2) | Prostaglandin-endoperoxide synthase 2 | 8.3 | 28.0 | 18.8 | 11.3 |
| Chia1 | Chitinase, acidic | −1.7 | −2.0 | −3.4 | −4.9 |
| Stat1 | Signal transducer and activator of transcription 1 | −2.5 | 2.2 | −1.1 | −2.6 |
| C3 | Complement component 3 | 2.6 | 6.0 | 2.2 | 1.1 |
| C5ar1 | Complement component 5a receptor 1 | 3.4 | 2.7 | 2.8 | 1.5 |
| Fcgr3 | Fc receptor, IgG, low affinity III | 4.9 | 1.4 | 1.5 | −1.3 |
∗Genes In bold lettering had their transcript levels significantly modulated (FC ≥ 2 or ≤ −2 and p value < 0.05 as described in Section 2). Positive and negative values represent genes with expression induced and repressed, respectively.