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. 2015 Oct 12;2015:856707. doi: 10.1155/2015/856707

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Copyright © 2015 Priscila de Matos Silva et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mechanism of action of CTLA4-Ig on DC. CTLA4-Ig soluble molecule binds to B7 (CD80/CD86) molecules on DC. CTLA4 presents a higher affinity to B7 molecule and competes with CD28 for this ligation. This interaction induces downregulation of B7 gene transcription and upregulation of IDO as well as secretion of sHLA-G. sHLA-G can stimulate Th2 and inhibit Th1 profile. DC: dendritic cell; CTLA4-Ig: extracellular domain of human CTLA4 with a portion of the Fc region of IgG; IDO: indoleamine 2,3-dioxygenase; sHLA-G: soluble HLA-G; Th: T helper; IL: interleukin; IFN: interferon; TNF: tumor necrosis factor.