Table 2. Comparison of clinical characteristics between patients with tolerated and failed UE.
| Clinical characteristic | Tolerated (n=17) | Failed (n=13) | p-value |
|---|---|---|---|
| Age, yr | 69.4±15.9 | 73.1±6.6 | 0.399 |
| Male | 15 (88.2) | 9 (69.2) | 0.360 |
| Cause of ICU admission | 0.553 | ||
| Pneumonia | 9 (52.9) | 7 (53.8) | |
| Septic shock | 2 (11.8) | 0 | |
| AECOPD | 3 (17.6) | 4 (30.8) | |
| Others | 3 (17.6) | 2 (15.4) | |
| Underlying disease | |||
| DM | 6 (35.3) | 4 (30.8) | >0.999 |
| HTN | 9 (52.9) | 6 (46.2) | >0.999 |
| TB | 3 (17.6) | 3 (23.1) | >0.999 |
| CKD | 3 (17.6) | 2 (15.4) | >0.999 |
| HF | 2 (11.8) | 5 (38.5) | 0.190 |
| APACHE II | 16.9±9.1 | 16.0±5.9 | 0.778 |
| SOFA score | 7.5±3.2 | 5.1±2.9 | 0.051 |
| Septic shock | 7 (41.2) | 0 | 0.023 |
| ARDS | 4 (23.5) | 4 (36.4) | 0.671 |
| Physiologic and laboratory parameter | |||
| Systolic BP | 132.4±13.1 | 135.3±22.6 | 0.685 |
| Diastolic BP | 80.3±9.1 | 76.0±16.1 | 0.400 |
| HR, 1/min | 99.5±18.9 | 103.7±19.1 | 0.557 |
| RR, 1/min | 22.2±3.5 | 24.7±5.9 | 0.195 |
| pH | 7.41±0.10 | 7.42±0.07 | 0.664 |
| PaCO2, mm Hg | 37.5±10.3 | 46.3±18.2 | 0.136 |
| PaO2, mm Hg | 87.5±21.3 | 81.5±27.3 | 0.509 |
| HCO3, mmol/L | 23.2±5.1 | 28.5±8.4 | 0.064 |
| SpO2, % | 95.8±2.2 | 95.7±2.3 | 0.853 |
| FiO2 | 35.4±8.8 | 38.1±5.6 | 0.339 |
| Ventilatory support | |||
| ACMV | 1 (5.9) | 2 (15.4) | 0.565 |
| SIMV | 5 (29.4) | 2 (15.4) | 0.427 |
| CPAP | 8 (47.1) | 7 (53.8) | >0.999 |
| T-piece | 3 (17.6) | 2 (15.4) | >0.999 |
| Use of sedative agents | 2 (11.8) | 2 (15.4) | >0.999 |
| Use of inotropic agents | 2 (11.8) | 1 (7.7) | >0.999 |
| Duration of MV, day | 5.9±5.9 | 19.4±15.1 | 0.015 |
| LOS in ICU, day | 7.1±6.5 | 18.1±14.2 | 0.009 |
| LOS in hospital, day | 25.8±23.8 | 41.6±34.8 | 0.167 |
| Mortality | 1 (5.9) | 6 (54.5)* | 0.007 |
Values are presented as mean±SD or number (%).
*Two patients were not reintubated at the request of the families. Accordingly, we have excluded these patients from comparisons of mortality. Nine unplanned extubation patients died in this study.
UE: unplanned extubation; ICU: intensive care unit; AECOPD: chronic obstructive pulmonary disease acute exacerbation; DM: diabetes mellitus; HTN: hypertension; TB: tuberculosis; CKD: chronic kidney disease; HF: heart failure; APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; ARDS: acute respiratory distress syndrome; BP: blood pressure; HR: heart rate; RR: respiratory rate; PaCO2: partial alveolar pressure of CO2; PaO2: partial pressure of alveolar O2; SpO2: O2 saturation; FiO2: fraction of inspired O2; ACMV: assist control mechanical ventilation; SIMV: synchronized intermittent mandatory ventilation; CPAP: continuous positive airway pressure; MV: mechanical ventilation; LOS: length of stay.