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. 2015 Oct 26;5:15636. doi: 10.1038/srep15636

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^99mTc-hexamethylpropyleneamineoxime (HMPAO) was chosen as one of the proper radiotracers for exosome labeling. After highly lipophilic ^99mTc-HMPAO enters the ENVs, endogenous glutathione in ENVs begins to convert ^99mTc-HMPAO to hydrophilic form, which is trapped inside ENVs.