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. 2015 Oct 26;5:15636. doi: 10.1038/srep15636

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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After intravenous injection of ^99mTc-HMPAO-ENVs or ^99mTc-HMPAO, SPECT/CT images were acquired at 30 min, 3 hr, and 5 hr in BALB/c mice. (a) The SPECT/CT imaging showed the significantly intense uptake of ^99mTc-HMPAO-ENVs in the liver and radioactivity in the salivary glands and intestine until 5 hr. (b) In contrast, high brain uptake and the delayed salivary glands uptake were observed in ^99mTc-HMPAO-injected mouse group.