Table 1. Binding affinities (Kds) of SKLB-677 with FLT3, various FLT3 mutants, and a set of selected kinases.

Kinase	SKLB-677 (Kd, nM)	Kinase	SKLB-677 (Kd, nM)
FLT3-wt	0.74	MET	220
FLT3-D835H	0.74	FGFR1	600
FLT3-D835Y	1.3	CDK2	>10000
FLT3-ITD	1.3	BTK	>10000
PDGFRα	12	DCLK1	>10000
PDGFRβ	2.7	ERBB2	>10000
KIT	3.1	MAST1	>10000
LOK	5.1	PAK4	>10000
VEGFR2	11	PLK2	>10000
TIE2	99	ROCK1	>10000
LCK	130	TGFBR1	>10000