Figure 1.

Statistical parametric maps (SPMs) showing regional grey matter atrophy significantly associated with altered pain and/or temperature responsiveness in the FTLD cohort. See also Table 3. SPMs are based on the contrast between patient subgroups with and without symptoms in the combined cohort (All FTLD, top) and in patients with C9orf72 mutations (C9orf72; all symptomatic) versus symptomatic patients without C9orf72 mutations (bottom). SPMs are thresholded for display purposes at P < 0.001 uncorrected for multiple comparisons over the whole brain and rendered on sections of a group mean T₁-weighted magnetic resonance brain template image in MNI standard space; coordinates (mm) of the plane of each section are indicated and the right hemisphere is shown on the right of the coronal sections and the axial section (bottom right, magnified to show thalamic anatomy). Z-scores for the SPMs are scaled according to the colour bar.