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. Author manuscript; available in PMC: 2015 Oct 26.
Published in final edited form as: Crit Care Med. 2014 Apr;42(4):781–789. doi: 10.1097/CCM.0000000000000106

Figure 3.

Figure 3

The calibrated classification tree based on the combination of all subjects in the derivation and test cohorts (calibration cohort, n = 672). The classification tree consists of 11 decision points and 22 daughter nodes. The classification tree includes six of the 12 candidate stratification biomarkers: C-C chemokine ligand 3 (CCL3), heat shock protein 70 kDa 1B (HSPA1B), interleukin-8 (IL8), granzyme B (GZMB), C-C chemokine ligand 4 (CCL4), and interleukin-1α (IL1A). The classification tree also includes serum lactate concentrations (mmol/L), age (yr), and the presence/absence of chronic disease as defined in the Methods section. The conventions of the calibrated classification tree are the same as that described for Figure 1. Terminal nodes 1, 3, 4, 6, 8, and 10 are considered low-risk terminal nodes, whereas terminal nodes 2, 5, 7, 9, 11, and 12 are considered high-risk terminal nodes.

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