Figure 2.

Schematic of CXCR1 and 2 signaling pathways. These receptors are 7-transmembrane G-protein–coupled receptors that bind to Gαi, Gα14, and Gα16 and activate PKA, PKC, and MAPK pathways, to promote migration and proliferation. These receptors are highly expressed on macrophages and to a lesser extent, endothelial cells. These receptors promote angiogenesis. AKT, protein kinase B; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated protein kinase kinase; PKA, cAMP-dependent protein kinase; PLC, phospholipase C; PKC, protein kinase C.