Table 3.
Synopsis of current preclinical and clinical studies showing promise in healing chronic wounds through changes in the expression of chemokines
| Study Title | Study Design | Chemokines Implicated | Outcome |
|---|---|---|---|
| Weinheimer-Haus et al.46 | Application of low-intensity vibration (diabetic mouse skin wound) | Increased expression levels of MCP-1 | Enhanced healing in diabetic wounds |
| Stenstresser et al.64 | Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide (diabetic mouse skin wound) | Increased expression levels of SDF-1 alpha and CXCR4 receptor | Promoted healing in diabetic wounds |
| Castilla et al.51 | Ex vivo priming of BMDSCs with SDF-1 alpha (diabetic mouse skin wound) | Increased expression levels of SDF-1 alpha in wounds | Promoted healing in diabetic wounds |
| Lima et al.65 | Topical application of insulin (preclinical model; diabetic mouse skin wound and clinical trial; diabetic ulcer patients) | Increased expression levels of SDF-1 alpha | Improved healing in diabetic wounds |
| Schǖrmann et al.66 | Oral administration of linagliptin (diabetic mouse skin wound) | Decreased expression levels of MIP-2 | Beneficial in healing of diabetic wounds |
| Nishimura et al.53 | Application of CXCR4 antagonist AMD3100 (diabetic mouse skin wound) | Increased expression levels of SDF-1 alpha | Promoted healing in diabetic wounds |
| Bermudez et al.52 | Inhibition of SDF-1 alpha levels in a diabetic mouse skin wound | Inhibition of SDF-1 alpha levels | Decreased the rate of healing in diabetic wounds |
| Nguyen et al.67 | Topical silencing of p53 in diabetic mouse skin wound | Increased expression levels of SDF-1 alpha | Improved healing in diabetic wounds |
| Liu et al.68 | Topical injection of SDF-1 alpha engineered bone marrow-derived fibroblasts in diabetic mouse skin wound | Increased expression levels of SDF-1 alpha | Improved healing in diabetic wounds |
| Restivo et al.50 | Topical application of CXCL12 expression plasmid in diabetic mouse skin wound | Increased expression levels of CXCL12 | Improved healing in diabetic wounds |
| de Leon et al.69 | Treating chronic wounds with platelet-rich plasma (PRP) gel (clinical trial) | Increase in the levels of chemokines reported | PRP can restart the healing process in chronic wounds |
| Badillo et al.70 | Treatment with lentiviral construct containing SDF-1 alpha gene (diabetic mouse skin wound) | Overproduction of SDF-1 alpha levels | Improved healing in diabetic wounds |