Figure 5.

SOX15 expression in esophageal adenocarcinomas (EACs). (A) Gene coexpression profiles for SOX15 (left) and CDX2 (right) in a large collection of normal, Barrett’s esophagus (BE), and EAC epithelium.²² We found that 317 transcripts correlated strongly (r >0.81) with SOX15 mRNA levels in normal esophagus and in approximately one-third of 75 EACs in this series. The 100 most highly correlated genes are shown. (B) Gene Ontology (GO) term enrichment among these 317 SOX15-coexpressed genes. (C) Top: Fraction of SOX15 coexpressed genes showing SOX15 occupancy (observed) within 50 kb compared with the fraction expected for appropriate random gene sets of equal size. Bottom: Fraction of SOX15 coexpressed genes affected by SOX15 depletion (observed) compared with the fraction expected among random gene sets of equal size. (D) Ranges of SOX15 mRNA expression extracted from RNA-seq data on the Cancer Genome Atlas collection of cancers of the gastric cardia, fundus/body, and antrum,²³ or colon and rectum.²⁴ Statistical significance of the differences was determined by t-test.