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. 2015 Oct 26;19:21. doi: 10.1186/s40824-015-0042-2

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© Jo et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scheme 1 — The pancreatic islet and HMGB1 A box protein were co-encapsulated in the alginate bead. The encapsulated HMGB1 A box protein may protect islets from HMGB1-mediated inflammation via competitive inhibition against TLR and/or RAGE on immune cells. By this action, this co-encapsulation of HMGB1 A box protein could reduce early graft loss in islet transplantation