Table 3.
Weight-drop TBI models.
| Study | Sex/species/age | Model | Injuries | Interval | Anesthesia | Outcome measures |
|---|---|---|---|---|---|---|
| DeFord et al. (72) | Male C57BL6 mice 2–3 months |
Weight-drop Closed head |
Single Repeat (4) |
Single (24 h) | Isoflurane N2O and O2 (70:30) |
Neuroscore; cell death; vascular damage; cardiovascular; cognition |
| Creeley et al. (48) | Male C57BL6 mice 2–3 months |
Weight-drop Closed head |
Repeat (3) | 24 h | Isoflurane | Motor; cognition; righting reflex; cell death |
| Fujita et al. (53) | Male S. Dawley rats 3–6 months |
Weight-drop Skull-exposed |
Single Repeat mild (2, 3) Repeat medium (2) Repeat severe (2) |
Single Two mild over 3 h Three mild over 2 h Two medium over 3 h Two severe over 3 h Two severe over 5 h Two severe over 10 h |
Pentobarbital | Vascular reactivity to ACh; axonal damage |
| Meehan et al. (54) | Male C57BL6 mice 2–3 months |
Weight-drop Closed head |
Single Repeat daily (3,10) Repeat variable (5) |
Single Daily (3, 5, or 10) Weekly (5) Monthly (5) |
Isoflurane N2O and O2 (70:30) |
Edema; axonal and vascular damage; cell death; cognition |
| Mannix et al. (54) | Male C57BL6 mice 2–3 months |
Weight-drop Closed head |
Single Repeat daily (5,7) Repeat variable (5) |
Single Daily (5 or 7) Weekly (5) Biweekly (5) Monthly (5) |
Isoflurane N2O and O2 (70:30) |
Cognition; tauopathy; advanced imaging |
| Weil et al. (57) | Male Swiss web. mice 2–3 months |
Weight-drop Skull-exposed |
Single Repeat (2) |
Single 3 or 20 days | Isoflurane | Glucose metabolism; inflammation; gliosis and degeneration; cell death; cognition |