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. 2015 Oct 26;6:537. doi: 10.3389/fimmu.2015.00537

Figure 2.

Figure 2

Cross-regulation of intracellular membrane-associated proteins and microRNAs in B cell differentiation. (a) Regulation of multiple intracellular membrane-associated proteins as well as AID (critical for CSR/SHM) and Blimp-1 (driving plasma cell differentiation) by a single microRNA. For example, miR-30a regulates Atg5, Beclin 1 and Atg12 in autophagy and Blimp-1, miR-30c regulates Rab7 (in the endosome pathway) and AID, as well, miR-93 and miR-181b regulate AID as well as Atg16L1 and Atg5, respectively. (b) Regulation of one intracellular membrane-associated protein by several microRNAs. For example, Rab7 is regulated by both miR-30c and miR-302b, and Atg12 is regulated by both miR-30a and miR-23b. (c) Regulation of microRNA activities by endosomes and autophagosomes. Endosomes provide a structure to support the assembly of RISC in microRNA-mediated gene silencing. Autophagosomes promote degradation of Dicer and Ago, thereby downregulating microRNA biogenesis and functions, respectively.