Table 1.
MicroRNAs target intracellular membrane-associated proteins and factors critical for B cell differentiation and functions.
| MicroRNAs | Intracellular membrane-associated protein target | Specific factor target | Relevant B cell function | Reference |
|---|---|---|---|---|
| miR-17-92 | TBC1D2, Atg7 | Bim, Pten | B cell development, Germinal center reaction | (66, 73, 76, 84) |
| miR-23b | Atg12, Atg2Ba, RAB11FIP2a | Blimp-1 | Plasma cell differentiation | (64, 85) |
| miR-30b | Rab7a | AIDa | CSR | (64, 79, 80) |
| Atg5, Beclin 1, Atg12a | Blimp-1 | Plasma cell differentiation | ||
| miR-155 | Rheb, Rictor | AID | CSR, SHM, Germinal center reaction | (60, 86, 87) |
| SHIP-1 | ||||
| miR-181b | Atg5 | AID | CSR | (61, 88) |
| miR-93 | Atg16L1, SQSTM1, Atg14a, RB1CC1a, ULK1a | AID | CSR | (82, 84, 89) |
| miR-302b | Rab7a, RABGAP1a, Rab9Aa | IRAK4 | NF-κB activation | (81) |
| miR-9 | Atg14a, ULK2a | NF-κB | CSR | (90) |
| miR-10a | RB1CC1 | BCL6 | Germinal center reaction | (91, 92) |
| miR-146a | SQSTM1a | TRAF6 | NF-κB activation | (93) |
aHigh confident targets predicted by miRDB (www.miRDB.org) (94).
bRab7 and AID are predicted to be targeted by miR-30c, with others being targets of miR-30a.