Fig. 6.

Model describing β-cell resilience where the functional form for their transformation to dysfunctional β-cells is given by $\frac{a_1{T}_b{B}_f}{k_1+T_b}$ and hence is considered to be dependent solely on the T cells that have become resistant to regulator T cell responses. The panels allow for one (top) islet autoantibody, two (middle), and three (bottom). In each case we set a₁ = 8 per day and then double it and then triple its value. In all cases, the level of functioning β-cells decreases as a₁ increases and in fact, there exists a dramatic drop when we allow for three islet autoantibodies and let a₁ > 18 as seen in the bottom panel.