. 2015 Oct 26;15:455. doi: 10.1186/s12879-015-1216-1

Table 4.

Summary of studies examining the incidence of and risk factors for recurrent SSTI in HIV-infected adults

Study	Population	Methodology	Outcome	Recurrence rate	Risk factors for recurrence
Crum-Cianflone et al. [10]	31 subjects with initial MRSA SSTI	Retrospective, single center	Any recurrent SSTI	41 % (all SSTI)	Lower CD4 count^a
				21 % (MRSA SSTI)	Higher viral load^ab
					Lack of incision and drainage^ab
					Positive nare culture^a
Crum-Cianflone et al. [26]	379 subjects with initial SSTI	Prospective, multi-center	Any recurrent SSTI	31 %	No significant risk factor identified
Crum-Cianflone et al. [26]	379 subjects with initial SSTI	Prospective, multi-center	Any recurrent SSTI	31 %	Trend toward viral load and dermatologic condition predicting SSTI recurrence
Graber et al. [9]	62 subjects with initial MRSA SSTI	Retrospective, single center	Any recurrent SSTI	71 %	No significant risk factor identified
Vyas et al. [11]	63 individuals with initial MRSA SSTI	Retrospective, single center	Recurrent MRSA SSTI	27 %	Older age^a
					Lower CD4 count at initial SSTI^ab
					Lower nadir CD4 count^a
					Higher peak viral load^a
					Prior AIDS defining illness^a
					History of malignancy^a
					IVDU^*
					Use of antibiotic other than minocycline^ab
					Hospital admission^ab
					Surgery^a
Skiest et al. [12]	41 subjects with initial MRSA SSTI	Prospective, single center	Any recurrent SSTI	29.7 %	No significant risk factor identified
Present study	85 subjects with initial SSTI	Retrospective, single center	Any recurrent SSTI	35 % (raw)	Catheter^ab
					Non-viral liver disease^ab
					Non-African American race^ab
					Lymphedema^a
					IVDU^b

^aUnivariate analysis

^bMultivariate analysis