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. 2015 Oct 23;94(42):e1784. doi: 10.1097/MD.0000000000001784

FIGURE 3.

FIGURE 3

Correlation between pulmonary adenocarcinoma malignancy grade (low/moderate/high-grade) and EGFR status. Pulmonary adenocarcinoma was subdivided into low-grade adenocarcinoma (adenocarcinoma in situ, minimally invasive adenocarcinoma), intermediate-grade adenocarcinoma (invasive adenocarcinoma of lepidic, acinar, and papillary predominant types), and high-grade adenocarcinoma (invasive adenocarcinoma of solid predominant, micropapillary predominant, and mucinous variant types) based on prognosis. There was a high frequency of intermediate-grade adenocarcinoma in the EGFR Ex19 group and a low frequency in the Wt group. There was a high frequency of high-grade adenocarcinoma in the Wt group and a low frequency in the EGFR exon 21 point mutation (Ex21) and Ex19 groups. There tended to be more low-grade adenocarcinoma in the Ex21 group compared to the Ex19 and Wt groups (not significant). EGFR = epidermal growth factor receptor, Ex19 = exon 19 deletion, Ex21 = exon 21 L858R point mutation, Wt = wild-type.