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. 2015 Oct 6;112(42):13109–13114. doi: 10.1073/pnas.1512243112

Fig. 2.

Fig. 2.

Effects of optogenetic activation of ARN kisspeptin neurons on LH secretion in male mice. (A and B) Representative examples showing LH secretion in response to blue light activation of ARN kisspeptin neurons (indicated by blue bars, 5-min each) at different frequencies in control and Kiss-Cre male mice. (C) Summary graphs showing mean ± SEM changes in LH secretion in response to 2-, 5-, 10-, and 20-Hz activation of ARN kisspeptin neurons in control male (open circle, n = 7) and Kiss-Cre male (closed circle, n = 6) mice. Circles in red indicate LH levels significantly elevated compared with prestimulation values for each frequency (P < 0.05; repeated-measures ANOVA with Dunnett’s post hoc test).