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. 2015 Sep 14;112(42):E5699–E5705. doi: 10.1073/pnas.1516465112

Fig. S2.

Fig. S2.

cGAS is essential for ISG expression in Trex1−/− mice. (A) qRT-PCR analysis of indicated ISGs, TNF-α, and IL12p40 in hearts from 12-wk-old mice of indicated genotypes. Fold changes are relative to Trex+/− mice. (B) qRT-PCR analysis of indicated ISGs, TNF-α, and IL12p40 in kidneys from 12-wk-old mice. Fold changes are relative to Trex1−/−cGas−/−mice. (C) qRT-PCR analysis of indicated ISGs in PBMCs from 5-wk-old mice. Fold changes are relative to Trex1−/−cGas−/−mice. (D) Measurement of IL-12 (total) in the plasma of 12-wk-old mice. Error bars represent SD. *P < 0.05; **P < 0.01; ***P < 0.001.