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cGAS is required for ISG induction in different cells types from Trex1−/− mice. GM-CSF–derived BMDCs (A), BMDMs (B), and mouse embryonic fibroblasts (MEF; C) from indicated genotypes were analyzed by qRT-PCR for expression of ISGs. Fold changes are relative to Trex1−/−cGas−/−mice. Error bars represent SD of triplicate assays. *P < 0.05; **P < 0.01; ***P < 0.001.
