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cGAS is essential for infiltration of autoreactive immune cells in the hearts of Trex1−/− mice. qRT-PCR analysis of IFN-γ (A and B) or T-bet (C and D) RNA in hearts from 12-wk-old mice of indicated genotypes is shown. Fold changes are relative to Trex1+/− (A and C) or Trex1−/−cGas−/− (B and D). Error bars represent SD. **P < 0.01; ***P < 0.001.
