Fig. S3.

The genes commonly up-regulated at late time points compared with early time points belong to four GO categories: cell cycle, chromatin organization, neuron, and muscle organ development. Log₂ ratios of the expression levels of genes up-regulated at late, compared with early, time points in each corresponding time series. Only genes up-regulated in at least both the R1 and R4 cell lines are displayed. In the heat maps, blue indicates a decrease in gene expression; yellow indicates an increase in gene expression; gray indicates no Affymetrix probeset. Color coding of gene targets: yellow squares indicate gene targets of the E2F pathway; red squares indicate gene targets of the E2F pathway that are rate-limiting for E2F-dependent proliferation; the orange square indicates a component of PRC1; the pink squares indicate components of PRC2.