Fig. 1.

Cartoon illustrating the underlying biology and data gathering at a single time point (Left) and time series modeling (Right). The data are from pol-II ChIP-Seq, summarized over the last 20% of the gene body, and RNA-Seq computationally split to pre-mRNA and different mRNA transcript expression levels. The modeling on the right shows the effect of changing mRNA half-life ($t_{1/2}$) or RNA production delay ($\mathrm{\Delta }$) on the model response: both induce a delay on the mRNA peak relative to the pol-II peak, but the profiles have otherwise distinct shapes.