Figure 1.

A flowchart describing functional genomics-based approach for BRD diagnostics. The availability of sequenced genomes for bovine and BRD pathogens enables the study of genome expression using various high-throughput approaches such as microarrays, RNA-seq, and proteomics, which often generate a list of genes/proteins. Continuous updates to existing structural and functional annotations enhance the quality of functional genomics findings. At the core of these annotation approaches as well as analysis of functional genomics data in the context of biological pathways and networks is the necessary bioinformatics analysis and resources. An integrated systems biology framework for analyzing functional genomics data is expected to identify accurate biomarkers for prediction of BRD resistance and susceptibility, as well as disease stratification.