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. Author manuscript; available in PMC: 2015 Oct 26.
Published in final edited form as: J Sep Sci. 2011 Jun 10;34(0):2255–2263. doi: 10.1002/jssc.201100280

Table 2. Dissociation rate constants measured for various drugs with AGP.

Drug Association Equilibrium Constant,
Ka (M−1) [Ref.]		 Dissociation Rate Constant,
kd (s−1)a
Amitriptyline 0.13–3.4 × 105 [27, 44] 0.39 (± 0.01)
Nortriptyline 0.2-1.2 × 105 [27] 0.42 (± 0.01)
Lidocaine 1.1-1.7 × 105 [30, 41] 0.73 (± 0.07)
a

All of the kd values were measured at pH 7.4 and at 37 °C. The values in parentheses represent a range of ± 1 S.D., as determined for the slopes of the best-fit lines for the logarithmic elution profiles.