Table 1.
A summary of articles using the Brief Pain Inventory (BPI) to assess QOL.
| Article authors (year) | Population and time of accrual | Questionnaire administration | Responders | Non-responders | Ref |
|---|---|---|---|---|---|
| Wu et al. (2006) | July 2002–July 2005 | Baseline and 4–6 weeks post treatment | Overall pain response of 72% | NA | [11] |
| All patients treated with palliative radiation for bone metastases | Significant reduction for all 7 functional interference items after treatment with greatest improvement seen in general activity | ||||
| N=109 | |||||
| Harris et al. (2007) | May 2003–June 2005 | Baseline and 2 months post treatment | Significant decrease in functional interference scores in general activity, normal work, enjoyment of life, and average functional interference | No significant difference in functional interference scores | [15] |
| All patients treated with palliative radiation for bone metastases | Pain progression in 11%, 14%, and 13% (worst, average, current pain scores) | ||||
| N=199 | Overall response in 66%, 58%, and 54% for worst, average, and current pain scores, respectively | No change in pain for 23%, 28%, and 31% (worst, average, current pain scores) | |||
| Hadi et al. (2008) | May 2003–Jan 2007 | Baseline and Months 1, 2, and 3 post treatment | All symptom severities improved over time | NA | [4] |
| All patients treated with palliative radiation for bone metastases | All symptoms except for mood, relations with others, and sleep were related to responders | ||||
| N=348 | Response rates of 56.5%, 57.5%, and 66.7% at weeks 4, 8, and 12 respectively | ||||
| Nguyen et al. (2011) | May 2003–June 2005 | Baseline and Months 1, 2, and 3 post treatment | All pain scores and functional interference scores improved over time | All BPI scores were significantly improved following RT except for mood | [1] |
| All patients treated for spinal metastases | Mood was the only significant BPI functional item significantly related to responders | ||||
| N=109 | |||||
| Khan et al. (2011) | May 2003–June 2007 | Baseline and months 1, 2, and 3 post treatment | Improvement in sleep at week 4, 8, and 12 | Improvement in sleep at weeks 4 and 8, worsened at week 12 | [16] |
| Patients treated with radiation for bone metastases | |||||
| N=400 | |||||
| Zeng et al. (2012) | May 2003–June 2007 | Baseline and each month for 6 months post treatment | Improvement in pain and functional interference scores significantly related to responders, regardless of spine or non-spinal location, except for sleeping problems at month 2 and 4 | NA | [10] |
| Patients treated with radiation for bone metastases | |||||
| N=386 | |||||