Table 5. In vitro antimalarial activity of hydroxyethylamine based phthalimides on the growth of P. falciparum (3D7).
IC50 values for most potent compounds (5e, 6j, 6o, 6s) against CQ resistant strain (7GB) over 48 h incubation are shown in the brackets.
| Entry | IC50 values ± SE (μM) | Entry | IC50 values ± SE (μM) |
|---|---|---|---|
| 5a | 5.88 ± 0.23 | 6j | 1.33 ± 0.04 (3.60 ± 0.06) |
| 5b | 5.40 ± 0.06 | 6k | 4.59 ± 0.07 |
| 5c | 2.56 ± 0.06 | 6l | 3.36 ± 0.05 |
| 5d | 4.90 ± 0.01 | 6m | 6.96 ± 0.10 |
| 5e | 1.16 ± 0.04 (2.99 ± 0.19) | 6n | 3.14 ± 0.02 |
| 5f | 3.11 ± 0.11 | 6o | 1.25 ± 0.08 (3.01 ± 0.42) |
| 6a | 4.61 ± 0.06 | 6p | 3.28 ± 0.04 |
| 6b | 3.41 ± 0.03 | 6q | 8.54 ± 0.04 |
| 6c | 4.58 ± 0.04 | 6r | 5.12 ± 0.43 |
| 6d | 6.33 ± 0.13 | 6s | 1.30 ± 0.03 (3.15 ± 0.04) |
| 6e | 2.13 ± 0.02 | 6t | 7.28 ± 0.43 |
| 6f | 2.96 ± 0.43 | 6u | 3.24 ± 0.06 |
| 6g | 3.80 ± 0.03 | CQ | 0.059 ± 0.20 (1.32 ± 0.56) |
| 6h | 4.37 ± 0.07 | ART | 0.021 ± 0.18 |
| 6i | 5.27 ± 0.06 |