Table 2. Multivariable^a adjusted hazard ratios (MVHRs) and 95% confidence intervals (CIs) for pancreatic cancer mortality according to sex-specific categories of waist circumference and waist-to-hip ratio

Category	Categories of waist circumference (cm)b				Continuous (per 10 cm)	P value, test for trend	P value, Int sexc
	1	2	3	4
Deaths
M	200	415	262	129	1006
F	185	245	269	242	941
MVHR (95% CI)
M	1.00 (ref)	1.09 (0.92–1.29)	1.16 (0.96–1.40)	1.27 (1.01–1.60)	1.08 (1.02–1.15)	0.008	0.86
F	1.00 (ref)	1.12 (0.91–1.38)	1.38 (1.12–1.71)	1.38 (1.10–1.73)	1.09 (1.03–1.15)	0.002
M + F	1.00 (ref)	1.11 (0.98–1.27)	1.26 (1.10–1.45)	1.31 (1.12–1.54)	1.09 (1.04–1.13)	<0.0001
Adj for BMId
M + F	1.00 (ref)	1.08 (0.94–1.24)	1.19 (1.02–1.40)	1.19 (0.96–1.47)	1.07 (1.00–1.14)	0.05
Category	Categories of waist-to-hip ratioe				Continuous (per 0.1)	P value, test for trend	P value, Int sexc
	1	2	3	4
Deaths
M	134	240	176	180	730
F	107	182	175	274	738
MVHR (95% CI)
M	1.00 (ref)	1.05 (0.85–1.30)	1.04 (0.83–1.30)	1.32 (1.05–1.66)	1.12 (1.02–1.23)	0.02	0.80
F	1.00 (ref)	1.20 (0.94–1.52)	1.18 (0.92–1.50)	1.36 (1.08–1.71)	1.10 (1.01–1.21)	0.04
M + F	1.00 (ref)	1.11 (0.95–1.31)	1.11 (0.94–1.31)	1.33 (1.14–1.57)	1.11 (1.04–1.19)	0.002
Adj for BMId
M + F	1.00 (ref)	1.10 (0.94–1.29)	1.08 (0.91–1.28)	1.28 (1.08–1.51)	1.09 (1.02–1.17)	0.02

^aMultivariable models were stratified by cohort and used attained age as the underlying time metric. All multivariable models adjusted for race (white, black, Asian, other, or unknown), education (less than high school, high school graduate, some college, college graduate, postgraduate, or unknown), marital status (married, divorced, widowed, single, or unknown), grams of alcohol consumption (quartiles or unknown), overall physical activity level (cohort-specific quintiles or unknown), and smoking status (never smoked, former smoker who quit <20 years ago, former smoker who quit 20 or more years ago, former smoker but unknown number of years since quitting, smoker but unknown if current or former, current smoker, or smoking status unknown).

^bMale (M)-specific cut points for each category of waist circumference: category 1 (<90), category 2 (90 to <100), category 3 (100 to <110), category 4 (≥110). Female (F)-specific cut points for each category of waist circumference: category 1 (<70), category 2 (70 to <80), category 3(80 to <90), category 4 (≥90).

^cP value, test for interaction by sex.

^dIn addition to the covariates listed in footnote 1, this model was also adjusted for body mass index at baseline (continuous).

^eMale-specific cut points for each category of waist-to-hip ratio: category 1 (<0.90), category 2 (0.90 to <0.95), category 3 (0.95 to <1.0), category 4 (≥1.0). Female-specific cut points for each category of waist circumference: category 1 (<0.75), category 2 (0.75 to <0.80), category 3 (0.80 to <0.85), category 4 (≥0.85).