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. 2015 Oct 26;10(10):e0140975. doi: 10.1371/journal.pone.0140975

Fig 6. Nek11S is required for G2/M checkpoint arrest and cell survival.

Fig 6

A-L. Using the protocols described in Fig 1A for irradiation and Fig 3A for irinotecan treatment, HCT116 WT (A-C, G-I) and HCT116 p53-null (D-F, J-L) cells were transfected with siRNA oligonucleotides to co-deplete Nek11L and Nek11D (L/D), or deplete Nek11S or luciferase (siGL2). Histograms show the percentage of cycling cells at G2/M (A-F) and of total cells with sub-2n DNA (G-L). p values are relative to siGL2 for each treatment.