TABLE 1.
Frequency of reactivation from latency as influenced by host and virus genotypes
| Host genotype | Frequency of reactivationa |
Reactivation defectb (vCycKO vs WT GHV68) | |
|---|---|---|---|
| WT GHV68 | vCycKO | ||
| C57BL/6J | 1/19,588 | <1/1,000,000 | >51.05 |
| p18−/− × p27+/− | 1/5,152 | 1/26,363 | 5.12 |
| p18+/− | 1/3,198 | 1/9,908 | 3.10 |
| p18−/− | 1/1,297 | 1/3,162 | 2.44 |
a
Frequency of virus reactivation from latency as measured from peritoneal cells explanted onto MEF monolayers, comparing wild-type and v-cyclin-deficient (vCycKO) GHV68 at day 42 p.i. as calculated from ex vivo reactivation analyses shown in Fig. 1.
b
The fold reactivation defect was calculated as the quotient of the frequency of reactivation for vCycKO divided by the frequency of reactivation for wild-type GHV68.