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. 2015 Aug 19;89(21):10802–10820. doi: 10.1128/JVI.01440-15

TABLE 2.

Summary of Nef-specific CD8+ T-cell responses, infection outcome, and extent of sequence variation in the Nef RL10 epitope

Group Animal ID % tetramer+ CD8+ T cells on DOCa % Nef ORF-reactive CD8+ T cells at wk 2 post-rAd5b VL
 % of WT Nef RL10 reads
Peakc Set pointd Wk 2.4 p.i.e Wk 6 p.i.f
1 r01068 1.31 0.09 1.4 × 106 3.7 × 103 96.3 95
r04001 17 1.75 1.2 × 106 2.3 × 105 11.7 0
r06008 0.87 2.82 4.5 × 105 4.0 × 101 100 16
r08017 0.63 2.15 4.4 × 106 7.0 × 103 100 100
r08018 6.33 1.53 9.4 × 105 1.6 × 102 99.7 7.9
r08020 1.3 0.81 2.4 × 107 9.7 × 102 96.3 24.3
r09029 0.63 2.19 9.0 × 104 1.7 × 103 96.6 82.8
r09089 0.58 0.4 4.5 × 106 4.4 × 101 100 98
2 rh2099 NA 48.4 3.0 × 107 1.6 × 106 100 80
r97076 NA 0.01 7.4 × 105 9.1 × 103 99.8 96.8
r08016 NA 0.54 4.2 × 107 3.2 × 103 100 69.3
r08032 NA 0.07 3.0 × 106 7.7 × 102 100 1.7
r08054 NA 1.25 8.6 × 105 7.0 × 101 100 100
r09014 NA 8.41 1.2 × 106 7.0 × 103 100 97.1
r09037 NA 0.03 1.1 × 107 1.1 × 102 100 61.2
r09068 NA 0.32 1.0 × 107 4.1 × 104 100 47.8
3 r04087 NA NA 7.8 × 106 4.6 × 105 100 ND
r09092 NA NA 9.6 × 106 3.9 × 103 100 ND
a

Tetramer staining performed in PBMC on the day of the 1st SIV challenge (DOC). The graphical representation of these data is shown in Fig. 2A. NA, not applicable.

b

The percentages refer to the frequency of vaccine-induced CD8+ T cells responding to stimulation by the Nef ORF pool in an ICS assay performed at week 2 post-rAd5 boost. The graphical representation of these data is shown in Fig. 3A.

c

Highest VL measured within the first 4 weeks of infection. The values correspond to vRNA copies/ml of plasma. The graphical representation of these data is shown in Fig. 6D.

d

Set point VLs were determined as the geometric mean of VLs measured between week 10 p.i. and the last time point available for each animal. The values correspond to vRNA copies/ml of plasma. The graphical representation of these data is shown in Fig. 6E.

e

The graphical representation of these data is shown in Fig. 8.

f

The graphical representation of these data is shown in Fig. 7.