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Amino acid substitutions in rH5N3 genes after six serial passages in White Leghorn chickensa
| Virus passage | Substitution in rH5N3 genes |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PB2 (aa 466) | PB1 (aa 633) | PA (aa 263) | HA (aa 387) | NP (aa 371) | NA |
M1 (aa 97) | NS1 (aa 193) | NEP |
||||
| aa 82 | aa 293 | aa 329 | aa 36 | aa 52 | ||||||||
| P0 | D | S | T | N | M | E | R | A | V | R | E | M |
| P1 | D | S | T | N | T | G | R | A | V | R | E | M |
| P2 | D | R | T | N | T | G | K | A | V | R | E | T |
| P3 | D | R | T | D | T | G | K | T | V | R | E | T |
| P4 | D | R | T | D | T | G | K | T | I | R | E | T |
| P5 | N | R | K | D | T | G | K | T | I | Q | K | T |
| P6 | N | R | K | D | T | G | K | T | I | Q | K | T |
aa, amino acid.
