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. 2015 Aug 19;89(21):10841–10859. doi: 10.1128/JVI.01425-15

FIG 8.

FIG 8

Structure of Ad14P1 fiber knob compared to the structures of Ad14 (3F0Y) and Ad3 (1H7Z). (A) Amino acid sequence of a section of the Ad14 and Ad14P1 fiber knobs. Beta-sheets F, G, H, and I are shaded in gray. The two-amino-acid deletion in the F-G loop of Ad14P1 is indicated by an arrow. (B) Overlay of the structures of Ad14 (3F0Y) and Ad14P1. Ad14P1 is shown in dark blue with the F-G loop in cyan. Ad14 is shown in gray with the F-G loop highlighted in yellow. The KE deletion in Ad14P1 breaks the alpha helix as shown. (C) Close-up of the F-G loop with Ad14P1 shown in cyan and Ad14 shown in gray (top). In the bottom panel, residues for the F-G loop are shown and labeled with numbering as per that of Ad14P1. (D) Overlay of the structures of Ad3 (1H7Z), Ad14 (3F0Y), and Ad14P1. Structures are shown as cartoons with partial transparency. Ad3 is shown in light green with the F-G loop in bright green, Ad14 is shown in gray with the F-G loop in gray, and Ad14P1 is shown in dark blue with the F-G loop in cyan. (E) Close-up of the F-G loops for Ad3, Ad14, and Ad14P1 colored as described for panel C.