Table 2.
Clinicopathologic and molecular characteristics according to SOX2 expression and amplification
| Variable | SOX2 protein expression
|
SOX2 amplification
|
||||
|---|---|---|---|---|---|---|
| Negative (n=60) | Positive (n=85) | P | Negative (n=61) | Positive (n=50) | P | |
| Median age, years | 58.5163 | 61.5686 | 0.200 | 62.8521 | 60.8233 | 0.270 |
| Sex | 0.983 | 0.904 | ||||
| Female | 5 | 7 | 4 | 3 | ||
| Male | 55 | 78 | 57 | 47 | ||
| Smoking history | 0.005 | 0.861 | ||||
| <20 pack-years | 12 | 20 | 10 | 9 | ||
| 20–50 pack-years | 23 | 50 | 31 | 27 | ||
| >50 pack-years | 25 | 15 | 20 | 14 | ||
| Family history of malignant tumor | 0.021 | 0.370 | ||||
| Absent | 44 | 75 | 43 | 39 | ||
| Present | 16 | 10 | 18 | 11 | ||
| Type of surgical resection | 0.029 | 0.037 | ||||
| Wedge-shape excision | 0 | 2 | 1 | 1 | ||
| Segmentectomy | 0 | 0 | 0 | 0 | ||
| Pulmonary lobectomy | 56 | 64 | 54 | 35 | ||
| Pneumonectomy | 4 | 17 | 5 | 13 | ||
| Tumor differentiation | 0.997 | 0.586 | ||||
| Well | 2 | 3 | 2 | 1 | ||
| Moderate | 26 | 37 | 27 | 18 | ||
| Poor | 32 | 45 | 32 | 31 | ||
| Mean tumor diameter, cm | 4.557 | 4.021 | 0.115 | 4.193 | 4.598 | 0.341 |
| N status | 0.751 | 0.402 | ||||
| N0 | 33 | 49 | 33 | 31 | ||
| N1/2/3 | 27 | 36 | 28 | 19 | ||
| Pathologic stage | 0.268 | 0.289 | ||||
| I | 22 | 39 | 22 | 23 | ||
| II–IV | 38 | 46 | 39 | 27 | ||
| Pleural invasion | 0.667 | 0.139 | ||||
| Absent | 44 | 65 | 50 | 35 | ||
| Present | 16 | 20 | 11 | 15 | ||
| Mutational status | ||||||
| EGFR mutation | 2 | 2 | 1.000 | 2 | 2 | 1.000 |
| HER2 mutation | 1 | 0 | 0.414 | 1 | 0 | 1.000 |
| BRAF mutation | 0 | 1 | 1.000 | 0 | 0 | |
| FGFR fusion | 1 | 9 | 0.046 | 2 | 4 | 0.406 |
| PIK3CA mutation | 0 | 2 | 0.511 | 2 | 1 | 1.000 |
| NFE2L2 mutation | 1 | 3 | 0.642 | 2 | 3 | 0.656 |