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. 2015 Oct 16;9:5671–5686. doi: 10.2147/DDDT.S90082

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© 2015 Liang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Effect of DV1–BH3, TAT–DV1, and TAT–DV1–BH3 on tumor growth and metastasis in nude mice.

Notes: Nude mice were dosed with DV1–BH3, TAT–DV1, and TAT–DV1–BH3 for 23 days (n=7). (A) Alignment of tumor of each group after 23-day treatment. “D” in figure stands for tumor disappeared. (B) Alignment of metastatic liver after 23-day treatment. (C) Bar graph showing the tumor volume in mice treated with PBS, DV1–BH3, TAT–DV1, or TAT–DV1–BH3. (D) Bar graph showing the tumor mass on the 23rd day. Data are expressed as mean ± SD. *P<0.05 by one-way ANOVA.

Abbreviations: BH3, Bcl-2 homology 3; TAT, transactivator of transcription; PBS, phosphate-buffered saline; SD, standard deviation; ANOVA, analysis of variance.