Table 1.
Baseline patient characteristics by treatment cohorts
| Baseline characteristic | Duloxetine (n=556) | SSRI (n=776) | P-value |
|---|---|---|---|
| Age, mean (SD), years | 38.2 (10.2) | 37.9 (10.7) | 0.539 |
| Female, % | 51.8 | 59.8 | 0.004 |
| Region, % | <0.001 | ||
| Mexico | 29.1 | 51.5 | |
| East Asia | 41.4 | 29.0 | |
| The Middle East | 27.3 | 15.9 | |
| Others | 2.2 | 3.6 | |
| Age at first symptoms of MDD, mean (SD), years | 34.3 (10.6) | 33.3 (11.6) | 0.078 |
| BMI (kg/m2), mean (SD) | 24.6 (4.4) | 24.8 (4.3) | 0.277 |
| Living with a spouse/partner, % | 69.9 | 69.7 | 0.948 |
| Independent living (living in his/her own apartment or house), % | 12.4 | 19.3 | <0.001 |
| Educational attainment, % | 0.020 | ||
| ≤ Primary school | 6.3 | 9.7 | |
| Secondary school/occupational program | 42.3 | 45.2 | |
| ≥ University | 51.4 | 45.1 | |
| Employment status, % | 0.057 | ||
| Full time | 57.0 | 54.5 | |
| Economically inactive | 22.8 | 28.4 | |
| Unemployed/part-time | 20.1 | 17.1 | |
| CGI-S, mean (SD) | 4.5 (0.7) | 4.6 (0.7) | 0.292 |
| QIDS-SR16, mean (SD) | 14.2 (4.6) | 14.5 (5.0) | 0.356 |
| SSI-pain, mean (SD) | 15.2 (5.1) | 13.8 (5.0) | <0.001 |
| Had MDD episodes in the past 24 months, % | 66.2 | 65.3 | 0.747 |
| Number of comorbidities, % | 0.177 | ||
| 0 | 77.0 | 72.5 | |
| 1 | 17.5 | 21.2 | |
| 2+ | 5.4 | 6.2 | |
| Any treatments/therapies for depression in the past 24 months, % | 42.6 | 44.2 | 0.568 |
| Painful physical symptoms, % | 58.5 | 46.5 | <0.001 |
Abbreviations: BMI, body mass index; CGI-S, Clinical Global Impressions of Severity; MDD, major depressive disorder; QIDS-SR16, 16-item Quick Inventory of Depressive Symptomatology Self-Report; SD, standard deviation; SSI-pain, somatic symptom inventory; SSRI, selective serotonin reuptake inhibitor.