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. 2015 Oct 20;8:3029–3039. doi: 10.2147/OTT.S91035

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© 2015 Ren et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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FOXA1 knockdown suppresses tumor growth in nude mice.

Notes: (A) SGC-7901 cells that were transfected with FOXA1 shRNA or NT shRNA were injected subcutaneously into nude mice. Tumor growth curves showed that SGC-7901 cells with FOXA1 knockdown (n=6) exhibited a significant slower growth as compared with control cells (n=6). *P<0.05 by ANOVA. Scale bar: 1 cm. (B) Representative immunostaining of Ki-67 and quantitative analysis of Ki-67 positive cells showed that FOXA1 knockdown significantly reduced cell proliferation; n=6, *P<0.05 by t-test. Scale bar: 20 μm. (C) Representative staining of TUNEL and quantitative analysis of TUNEL positive cells revealed that FOXA1 knockdown significantly increased the number of apoptotic cells; n=6, *P<0.05 by t-test. Scale bar: 20 μm.

Abbreviations: FOXA1, forkhead box protein A1; NT, non-targeting; shRNA, short hairpin RNA; ANOVA, analysis of variance; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.