Table 1.
Clinical association analysis of FOXA1 expression in gastric cancer
| Clinicopathological features | Total no of patients, n=80 | No of patients
|
P-value | |
|---|---|---|---|---|
| Positive FOXA1 (%) | Negative FOXA1 (%) | |||
| Age (years) | ||||
| <65 | 41 | 29 (70.7) | 12 (29.3) | 0.119 |
| ≥65 | 39 | 21 (53.8) | 18 (46.2) | |
| Sex | ||||
| Male | 55 | 38 (69.1) | 17 (30.9) | 0.071 |
| Female | 25 | 12 (48.0) | 13 (52.0) | |
| Histology | ||||
| Well, moderate | 40 | 20 (50.0) | 20 (50.0) | 0.021* |
| Poor, signet | 40 | 30 (75.0) | 10 (25.0) | |
| Size (cm) | ||||
| <5 | 37 | 17 (45.9) | 20 (54.1) | 0.005* |
| ≥5 | 43 | 33 (76.7) | 10 (23.3) | |
| Depth | ||||
| T1 | 19 | 10 (52.6) | 9 (47.4) | 0.309 |
| T2–T4 | 61 | 40 (65.6) | 21 (34.4) | |
| Lymph node metastasis | ||||
| Absent | 28 | 18 (64.3) | 10 (35.7) | 0.809 |
| Present | 52 | 32 (61.5) | 20 (38.5) | |
| Lymphatic invasion | ||||
| Absent | 21 | 11 (52.4) | 10 (47.6) | 0.265 |
| Present | 59 | 39 (66.1) | 20 (33.9) | |
| Venous infiltration | ||||
| Absent | 57 | 36 (63.2) | 21 (36.8) | 0.848 |
| Present | 23 | 14 (60.9) | 9 (39.1) | |
| TNM stage | ||||
| I, II | 50 | 27 (54.0) | 23 (46.0) | 0.043* |
| III, IV | 30 | 23 (62.5) | 7 (37.5) | |
Note:
*
Statistically significant.
Abbreviations: FOXA1, forkhead box protein A1; TNM, tumor-node-metastasis; no, number.