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. 2015 Oct 19;10:6571–6585. doi: 10.2147/IJN.S88384

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© 2015 Tang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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ROS sensitive nanoparticles are formulated from PPADT and release intravenous delivered chemokine at sites of wound.

Notes: (A) When delivered intravenously, SDF-1α-PPADT nanoparticles remain stable in the normal environment of the blood vessels far away from wound protecting SDF-1α and preventing its release to normal tissues. However, in and around the blood vessels of wound, where tissues produce unusually high levels of ROS, the SDF-1α-PPADT nanoparticles degrade, thus releasing SDF-1α to the site of wound. (B) PPADT was synthesized using an acetal exchange reaction as previous described.

Abbreviations: ROS, reactive oxygen species; SDF-1α, stromal cell-derived factor-1α; h, hours; SDF-1α-PPADT, SDF-1α-loaded PPADT; PPADT, Poly-(1,4-phenyleneacetone dimethylene thioketal); PTSA, P-Toluene sulfonic acid.