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. 2015 Oct 19;10:6571–6585. doi: 10.2147/IJN.S88384

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© 2015 Tang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Toxicity analysis of nanoparticles.

Notes: (A) After cultured with PBS and 100 μg/mL, 1 mg/mL, 10 mg/mL SDF-1α-PPADT nanoparticles for 24 hours, the cell proliferation rates of BMSCs almost identical (P=0.638). (B) 7 days after injected intravenously with saline (control), 1 mg/kg, 10 mg/kg and 100 mg/kg. SDF-1α-PPADT nanoparticles, the injury markers CK (P=0.679), AST (P=0.853) and ALT (P=0.831) showed no significantly differences.

Abbreviations: CK, creatine kinase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; PBS, phosphate buffered saline; PPADT, poly-(1,4-phenyleneacetone dimethylene thioketal); SDF-1α-PPADT, SDF-1α-loaded PPADT; SDF-1α, stromal cell-derived factor-1α.